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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Lymphangiogenese</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p><b>Lymphangiogenese</b> ist das Wachstum neuer <a href="Lymphgef%C3%A4%C3%9F" title="Lymphgefäß">Lymphgefäße</a> von bereits existierenden Gefäßen<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> ähnlich dem Prozess der <a href="Angiogenese" title="Angiogenese">Angiogenese</a> (Wachstum der Blutgefäße). Davon abzugrenzen ist der Prozess der Lymphvaskulogenese (der de-novo-Bildung von lymphatischen Strukturen aus Vorläuferzellen)<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>.
</p><p>Lymphangiogenese spielt eine wichtige <a href="Physiologie" title="Physiologie">physiologische</a> Rolle in der <a href="Hom%C3%B6ostase" title="Homöostase">Homöostase</a>, im <a href="Stoffwechsel" title="Stoffwechsel">Stoffwechsel</a> und der <a href="Immunit%C3%A4t_(Medizin)" title="Immunität (Medizin)">Immunität</a>. Die unzureichende oder vermehrte Bildung von Lymphgefäßen ist charakteristisch für eine Reihe von Krankheiten, so z. B. für <a href="Tumor" title="Tumor">Tumor</a>-<a href="Metastasierung" class="mw-redirect" title="Metastasierung">Metastasierung</a>,<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> <a href="Lymph%C3%B6dem" title="Lymphödem">Lymphödem</a>, <a href="Lip%C3%B6dem" title="Lipödem">Lipödem</a>, <a href="Rheumatoide_Arthritis" title="Rheumatoide Arthritis">Rheumatoide Arthritis</a>, <a href="Psoriasis" class="mw-redirect" title="Psoriasis">Psoriasis</a>, <a href="Lymphangiomatosis" title="Lymphangiomatosis">Lymphangiomatosis</a> und verzögerte <a href="Wundheilung" title="Wundheilung">Wundheilung</a>.
</p><p>Die Rolle des <a href="Lymphsystem" class="mw-redirect" title="Lymphsystem">Lymphsystems</a> in diesen Krankheiten hat das Interesse an der Lymphangiogenese erneut geweckt, nicht zuletzt aufgrund der Entdeckung von Markern, die spezifisch für lymphatische <a href="Endothelzellen" class="mw-redirect" title="Endothelzellen">Endothelzellen</a> sind, wie dem Rezeptor des Vaskulären Endothelzell-Wachstumsfaktor C <a href="VEGF-C" title="VEGF-C">VEGF-C</a> (VEGFR-3), <a href="Podoplanin" title="Podoplanin">Podoplanin</a>, <a href="LYVE1" title="LYVE1">LYVE1</a>, PROX-1 und <a href="Desmoplakin" title="Desmoplakin">Desmoplakin</a>. Diese spezifischen Marker ermöglichten neue Erkenntnisse über die Funktion, Struktur und molekularbiologischen Grundlagen des Lymphsystems. Mehrere Faktoren sind bekannt, die die Lymphangiogenese anregen, unter anderen VEGF-C, <a href="Hyalurons%C3%A4ure" title="Hyaluronsäure">Hyaluronsäure</a> and Ephrin-B2.
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<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>Karl H. Plate: <cite style="font-style:italic">From angiogenesis to lymphangiogenesis</cite>. In: <cite style="font-style:italic">Nature Medicine</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>7</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, Februar 2001, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>151–152</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/84579">10.1038/84579</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Lymphangiogenese&rft.atitle=From+angiogenesis+to+lymphangiogenesis&rft.au=Karl+H.+Plate&rft.date=2001-02&rft.doi=10.1038%2F84579&rft.genre=journal&rft.issue=2&rft.jtitle=Nature+Medicine&rft.pages=151-152&rft.volume=7" style="display:none"> </span></li>
<li>Gavin Jell, <a href="Dontscho_Kerjaschki" title="Dontscho Kerjaschki">Dontscho Kerjaschki</a>, Peter Revell, Najat Al-Saffar: <cite style="font-style:italic">Lymphangiogenesis in the bone–implant interface of orthopedic implants: Importance and consequence</cite>. In: <cite style="font-style:italic">Journal of Biomedical Materials Research Part A</cite>. 77A, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 2006, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>119–127</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/jbm.a.30548">10.1002/jbm.a.30548</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Lymphangiogenese&rft.atitle=Lymphangiogenesis+in+the+bone-implant+interface+of+orthopedic+implants%3A+Importance+and+consequence&rft.au=Gavin+Jell%2C+Dontscho+Kerjaschki%2C+Peter+Revell%2C+...&rft.date=2006&rft.doi=10.1002%2Fjbm.a.30548&rft.genre=journal&rft.issue=1&rft.jtitle=Journal+of+Biomedical+Materials+Research+Part+A&rft.pages=119-127&rft.volume=77A" style="display:none"> </span></li>
<li>Rui-Cheng Ji: <cite style="font-style:italic">Lymphatic Endothelial Cells, Lymphangiogenesis, and Extracellular Matrix</cite>. In: <cite style="font-style:italic">Lymphatic Research and Biology</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>4</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, 1. Juni 2006, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>83–100</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1089/lrb.2006.4.83">10.1089/lrb.2006.4.83</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Lymphangiogenese&rft.atitle=Lymphatic+Endothelial+Cells%2C+Lymphangiogenesis%2C+and+Extracellular+Matrix&rft.au=Rui-Cheng+Ji&rft.date=2006-06-01&rft.doi=10.1089%2Flrb.2006.4.83&rft.genre=journal&rft.issue=2&rft.jtitle=Lymphatic+Research+and+Biology&rft.pages=83-100&rft.volume=4" style="display:none"> </span></li>
<li>Sawan Kumar Jha, Khushbu Rauniyar, Michael Jeltsch: <cite style="font-style:italic">Key molecules in lymphatic development, function, and identification</cite>. In: <cite style="font-style:italic">Annals of Anatomy - Anatomischer Anzeiger</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>219</span>, 2018, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>25–34</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.aanat.2018.05.003">10.1016/j.aanat.2018.05.003</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/de.wikipedia.org:Lymphangiogenese&rft.atitle=Key+molecules+in+lymphatic+development%2C+function%2C+and+identification&rft.au=Sawan+Kumar+Jha%2C+Khushbu+Rauniyar%2C+Michael+Jeltsch&rft.btitle=Annals+of+Anatomy+-+Anatomischer+Anzeiger&rft.date=2018&rft.doi=10.1016%2Fj.aanat.2018.05.003&rft.genre=book&rft.pages=25-34&rft.volume=219" style="display:none"> </span> (Übersichtsartikel zu den Markern lymphatischer Endothelzellen).</li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">Rainer Krebs, Michael Jeltsch: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Die lymphangiogenen Wachstumsfaktoren VEGF-C und VEGF-D. Teil 1: Grundlagen und Embryonalentwicklung</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Lymphologie in Forschung und Praxis</cite>. 17. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 2013, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>30–37</span> (englisch, <a rel="nofollow" class="external text" href="https://jeltsch.org/sites/jeltsch.org/files/JeltschMichael_Lymphforsch2013_30.pdf">jeltsch.org</a> [PDF]).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Lymphangiogenese&rft.atitle=Die+lymphangiogenen+Wachstumsfaktoren+VEGF-C+und+VEGF-D.+Teil+1%3A+Grundlagen+und+Embryonalentwicklung&rft.au=Rainer+Krebs%2C+Michael+Jeltsch&rft.date=2013&rft.genre=journal&rft.issue=1&rft.jtitle=Lymphologie+in+Forschung+und+Praxis&rft.pages=30-37&rft.volume=17.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">Kenny Mattonet, Michael Jeltsch: <cite style="font-style:italic">Über die heterogene Herkunft des Lymphgefäßsystems</cite>. In: <cite style="font-style:italic">Lymphologie in Forschung und Praxis</cite>. 19. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 2015, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>84–88</span> (<a rel="nofollow" class="external text" href="http://www.dglymph.de/fileadmin/global/pdfs/LymphForsch_2-15.pdf">dglymph.de</a> [PDF]).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Lymphangiogenese&rft.atitle=%C3%9Cber+die+heterogene+Herkunft+des+Lymphgef%C3%A4%C3%9Fsystems&rft.au=Kenny+Mattonet%2C+Michael+Jeltsch&rft.date=2015&rft.genre=journal&rft.issue=1&rft.jtitle=Lymphologie+in+Forschung+und+Praxis&rft.pages=84-88&rft.volume=19.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><span class="book">Steven A. Stacker: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Lymphangiogenesis in Cancer Metastasis</cite>. Springer, 2009, ISBN 978-90-481-2246-2, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>27<span style="display:inline-block;width:.2em"> </span>ff</span>. (englisch, <a rel="nofollow" class="external text" href="http://books.google.com/books?id=oIIB9NIAwFoC&pg=PA27">google.com</a> [abgerufen am 26. Juni 2010]).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/de.wikipedia.org:Lymphangiogenese&rft.au=Steven+A.+Stacker&rft.btitle=Lymphangiogenesis+in+Cancer+Metastasis&rft.date=2009-07-01&rft.genre=book&rft.isbn=9789048122462&rft.pages=27+ff&rft.pub=Springer" style="display:none"> </span></span></span>
</li>
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